Felix A. Ruiz, Ph.D.
Professor. College of Medicine at the University of Cadiz, Spain.

Address: Hospital Universitario "Puerta de Mar",
Unidad de Investigación. 9ª planta,
Avda. Ana de Viya, 21, 11009-Cadiz, SPAIN

Phone: 34-956003156
Fax: 34-956002347

email: felix.ruiz at uca.es


Researcher of the Spanish Ramón y Cajal Program, University of Cadiz, Spain. (2004-2008)
Postdoctoral Research Associate, University of Illinois, USA. (2000-2004)
Postdoctoral Fellow, Universidad de Navarra, Spain. (1998-2000)
Ph.D., Universidad Autónoma de Madrid, Spain. (1998)
M.S., Universidad Central de Venezuela, Venezuela. (1996)

Since the summer of 2004, I am the Principal Investigator of the Human Phosphate Research Group (Hupho Group), interested in the study of phosphate polymers in human cells and tissues.


31- Moreno-Sanchez D, Hernandez-Ruiz L, Ruiz FA*, Docampo R.*. (2012) Polyphosphate is a novel pro-inflammatory regulator of mast cells and is located in acidocalcisomes. J Biol Chem. 2012 Jul 3. [Epub ahead of print] *Corresponding authors

30- Jimenez-Nunez MD, Moreno-Sanchez D, Hernandez-Ruiz L, Benitez-Rondan A, Ramos-Amaya A, Rodriguez-Bayona B, Medina F, Brieva JA, Ruiz FA.*. (2012) Myeloma cells contain high inorganic polyphosphate levels that are associated with nucleolar transcription. Haematologica. 2012 Feb 7. [Epub ahead of print] *Corresponding author

29- Hernández-Ruiz L, Sáez-Benito A, Pujol-Moix N, Rodríguez-Martorell J, Ruiz FA*. (2009) Platelet inorganic polyphosphate decreases in patients with delta storage pool disease. J Thromb Haemost. 7(2):361-3. *Corresponding author

28- Muhl L, Galuska SP, Oörni K, Hernández-Ruiz L, Andrei-Selmer LC, Geyer R, Preissner KT, Ruiz FA, Kovanen PT, Kanse SM. (2009) High negative charge-to-size ratio in polyphosphates and heparin regulates factor VII-activating protease. FEBS J. 276(17):4828-39.

27- Rabaneda LG, Carrasco M, López-Toledano MA, Murillo-Carretero M, Ruiz FA, Estrada C, Castro C. (2008) Homocysteine inhibits proliferation of neuronal precursors in the mouse adult brain by impairing the basic fibroblast growth factor signaling cascade and reducing extracellular regulated kinase 1/2-dependent cyclin E expression. FASEB J. 22(11):3823-35.

26- Hernandez-Ruiz L, Valverde F, Jimenez-Nunez MD, Ocana E, Saez-Benito A, Rodriguez-Martorell J, Bohorquez JC, Serrano A, Ruiz FA*. (2007) Organellar Proteomics of Human Platelet Dense Granules Reveals That 14-3-3zeta Is a Granule Protein Related to Atherosclerosis. J Proteome Res. 6(11):4449-57. *Corresponding author

25- Fang J, Ruiz FA, Docampo MD, Luo S, Rodrigues JC, Motta LS, Rohloff P, Docampo R. (2007) Overexpression of a Zn2+-sensitive soluble exopolyphosphatase from Trypanosoma cruzi depletes polyphosphate and affects osmoregulation. J Biol Chem. 282(44):32501-10.

24- Hernandez-Ruiz L, Gonzalez-Garcia I, Castro C, Brieva JA, Ruiz FA*. (2006) Inorganic polyphosphate and specific induction of apoptosis in human plasma cells. Haematologica. 91(9):1180-6. *Corresponding author

23- Luo S, Ruiz FA, Moreno SN. (2005) The acidocalcisome Ca2+-ATPase (TgA1) of Toxoplasma gondii is required for polyphosphate storage, intracellular calcium homeostasis and virulence. Mol Microbiol. 55(4):1034-45.

22- Ruiz FA, Lea CR, Oldfield E, Docampo R. (2004) Human platelet dense granules contain polyphosphate and are similar to acidocalcisomes of bacteria and unicellular eukaryotes. J Biol Chem. 279(43):44250-7.

21- Wetzel DM, Chen LA, Ruiz FA, Moreno SN, Sibley LD. (2004) Calcium-mediated protein secretion potentiates motility in Toxoplasma gondii. J Cell Sci. 117:5739-48.

20- Ruiz FA, Luo S, Moreno SN, Docampo R. (2004) Polyphosphate content and fine structure of acidocalcisomes of Plasmodium falciparum. Microsc Microanal. 10:563-7.

19- Arrizabalaga G, Ruiz FA, Moreno, SN, Boothroyd, JC. (2004) Ionophore-resistant mutant of Toxoplasma gondii reveals involvement of a sodium/hydrogen exchanger in calcium regulation. J. Cell Biol. 165(5):653-62

18- Lemercier G, Espiau B, Ruiz FA, Vieira M, Luo S, Baltz T, Docampo R, Bakalara N. (2004) A pyrophosphatase regulating polyphosphate metabolism in acidocalcisomes is essential for Trypanosoma brucei virulence in mice. J Biol Chem. 279(5):3420-5

17- Seufferheld M, Vieira MC, Ruiz FA, Rodrigues CO, Moreno SN, Docampo R. (2003) Identification of organelles in bacteria similar to acidocalcisomes of unicellular eukaryotes. J Biol Chem. 278(32):29971-8

16- Rodrigues CO, Ruiz FA, Vieira M, Hill JE, Docampo R. (2002) An acidocalcisomal exopolyphosphatase from Leishmania major with high affinity for short-chain polyphosphate. J Biol Chem. 277(52):50899-906

15- Rodrigues CO*, Ruiz FA*, Rohloff P, Scott DA, Moreno SN. (2002) Characterization of isolated acidocalcisomes from Toxoplasma gondii tachyzoites reveals a novel pool of hydrolysable polyphosphate. J Biol Chem. 277(50):48650-6 *Both authors contributed equally to this work

14- Lemercier G, Dutoya S, Luo S, Ruiz FA, Rodrigues CO, Baltz T, Docampo R, Bakalara N. (2002) A vacuolar-type H+-pyrophosphatase governs maintenance of functional acidocalcisomes and growth of the insect and mammalian forms of Trypanosoma brucei. J Biol Chem. 277(40):37369-37376

13- Corrales FJ, Perez-Mato I, Sanchez Del Pino MM, Ruiz F, Castro C, Garcia-Trevijano ER, Latasa U, Martinez-Chantar ML, Martinez-Cruz A, Avila MA, Mato JM. (2002) Regulation of mammalian liver methionine adenosyltransferase. J Nutr. 132:2377S-2381S.

12- Rodriguez-Ortigosa CM, Cincu RN, Sanz S, Ruiz F, Quiroga J, Prieto J.(2002) Effect of ursodeoxycholic acid on methionine adenosyltransferase activity and hepatic glutathione metabolism in rats. Gut. 50(5):701-6.

11- Marchesini N*, Ruiz FA*, Vieira M, Docampo R. (2002) Acidocalcisomes are functionally linked to the contractile vacuole of Dictyostelium discoideum. J Biol Chem. 277(10):8146-53. *Both authors contributed equally to this work

10- Ruiz FA, Marchesini N, Seufferheld M, Govindjee, Docampo R. (2001) The polyphosphate bodies of Chlamydomonas reinhardtii possess a proton pumping pyrophosphatase and are similar to acidocalcisomes. J Biol Chem. 276(49):46196-203

9- Furuya T, Okura M, Ruiz FA, Scott DA, Docampo R. (2001) TcSCA complements yeast mutants defective in Ca2+ pumps and encodes a Ca2+-ATPase that localizes to the endoplasmic reticulum of Trypanosoma cruzi. J Biol Chem. 276(35):32437-45.

8- Ruiz FA, Rodriguez CO, Docampo R. (2001) Rapid changes in polyphosphate content within acidocalcisomes in response to cell growth, differentiation and environmental stress in Trypanosoma cruzi. J Biol Chem. 276(28):26114-21.

7- Corrales FJ*, Ruiz F*, Mato JM. (1999) In vivo regulation by glutathione of methionine adenosyltransferase S-nitrosylation in rat liver. J Hepatol. 31(5):887-94. *Both authors contributed equally to this work

6- Castro C*, Ruiz FA*, Perez-Mato I, Sanchez del Pino MM, LeGros L, Geller AM, Kotb M, Corrales FJ, Mato JM. (1999) Creation of a functional S-nitrosylation site in vitro by single point mutation. FEBS Lett. 459(3):319-22. *Both authors contributed equally to this work

5- Perez-Mato I, Castro C, Ruiz FA, Corrales FJ, Mato JM. (1999) Methionine adenosyltransferase S-nitrosylation is regulated by the basic and acidic amino acids surrounding the target thiol. J Biol Chem. 274(24):17075-9.

4- Ruiz F*, Corrales FJ*, Miqueo C, Mato JM. (1998) Nitric oxide inactivates rat hepatic methionine adenosyltransferase In vivo by S-nitrosylation. Hepatology. 28(4):1051-7. *Both authors contributed equally to this work

3- Avila MA, Corrales FJ, Ruiz F, Sanchez-Gongora E, Mingorance J, Carretero MV, Mato JM. (1998) Specific interaction of methionine adenosyltransferase with free radicals. Biofactors. 8(1-2):27-32.

2- Sanchez-Gongora E, Ruiz F, Mingorance J, An W, Corrales FJ, Mato JM. (1997) Interaction of liver methionine adenosyltransferase with hydroxyl radical. FASEB J. 11(12):1013-9.

1- Benaim G, Moreno SN, Hutchinson G, Cervino V, Hermoso T, Romero PJ, Ruiz F, de Souza W, Docampo R. (1995) Characterization of the plasma-membrane calcium pump from Trypanosoma cruzi. Biochem J. 306:299-303.

This page was last updated on July 19th, 2012. Please send comments to felix.ruiz at uca.es

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