NeurHoM Research Group
Welcome to the “Neurons and Homocysteine Metabolism” research group. We are interested on studying the effects of elevated levels of plasma Hcy on the adult brain, and its role in the development of cognitive impairment. Currently our group is investigating the effects of homocysteine on the generation of neurons from neural progenitor cells at the molecular cellular and physiological levels.
Contact Information
Universidad de Cádiz
Facultad de Medicina
Area de Fisiología
Plaza Fragela, 9 Planta 4ª
Cádiz 11003
e-mail: carmen.castro(at)uca.es
NeurHoM People
Carmen Castro
Ramón y Cajal Researcher 2004-2009
Ph. D. Universidad Autónoma de Madrid 1998
Manuel Carrasco Viñuela
Prof. Ayudante Doctor
Ph. D. Universidad de Cádiz
Luis G. Rabaneda
FPU Fellowship 2007-2011
José M. Martínez Salas.
Universidad de Cádiz
NeurHoM Research Interests
Recent Publications
-Rabaneda L.G., Carrasco M., López-Toledano M.A., Murillo-Carretero M.I., Ruiz F.A., Estrada C., Castro C (2008). Homocysteine inhibits proliferation of neuronal precursors in the mouse adult brain by impairing the basic fibroblast growth factor signaling cascade and reducing extracellular regulated kinase 1/2- dependent cyclin E expression. FASEB J. Epub ahead of print: fj.08-109306v1 [PubMed].
-Castro C, Millian N.S., Garrow T.A. (2008). Liver Betaine-Homocysteine S-Methyltransferase Activity
Undergoes a Redox Switch at the Active Site Zinc. Arch. Biochem. Biophys. 472: 26-33 [PubMed]
-Szegedi S.S., Castro CC., Koutmos M., Garrow T.A. (2008) Betaine-Homocysteine S-methyltransferase-2 is an S-methylmethionine Homocysteine Methyltransferase. J. Biol. Chem. 283: 8939-45 [PubMed]
