NeurHoM Research Group


Welcome to the “Neurons and Homocysteine Metabolism” research group. We are interested on studying the effects of elevated levels of plasma Hcy on the adult brain, and its role in the development of cognitive impairment. Currently our group is investigating  the effects of homocysteine on the generation of neurons from neural progenitor cells at the molecular cellular and physiological levels.


Contact Information

Carmen Castro

Universidad de Cádiz

Facultad de Medicina

Area de Fisiología

Plaza Fragela, 9 Planta 4ª

Cádiz 11003

e-mail: carmen.castro(at)

NeurHoM People

Principal Investigator:

Carmen Castro

Ramón y Cajal Researcher 2004-2009

Ph. D. Universidad Autónoma de Madrid 1998


Manuel Carrasco Viñuela

Prof. Ayudante Doctor

Ph. D. Universidad de Cádiz

Ph.D. Students:

Luis G. Rabaneda

FPU Fellowship 2007-2011

M.D. Students

José M. Martínez Salas.

Universidad de Cádiz

List of Publications


NeurHoM Research Interests

Recent Publications

-Rabaneda L.G., Carrasco M., López-Toledano M.A., Murillo-Carretero M.I., Ruiz F.A., Estrada C., Castro C (2008). Homocysteine inhibits proliferation of neuronal precursors in the mouse adult brain by impairing the basic fibroblast growth factor signaling cascade and reducing extracellular regulated kinase 1/2- dependent cyclin E expression. FASEB J. Epub ahead of print: fj.08-109306v1 [PubMed].

-Castro C, Millian N.S., Garrow T.A. (2008). Liver Betaine-Homocysteine S-Methyltransferase Activity

Undergoes a Redox Switch at the Active Site Zinc. Arch. Biochem. Biophys. 472: 26-33 [PubMed]


-Szegedi S.S., Castro CC., Koutmos M., Garrow T.A. (2008) Betaine-Homocysteine S-methyltransferase-2 is an S-methylmethionine Homocysteine Methyltransferase. J. Biol. Chem. 283: 8939-45 [PubMed]