Grupo de
Investigación del Síndrome Metabólico y
Resistencia Insulínica /
Metabolic Syndrome and
Insulin Resistance
Research Group
Director: Dr.
Germán M. Perdomo
Hernández
Dirección / Address:
Hospital
Universitario
Puerta del Mar
Planta
9º. Unidad de Investigación
Avda. Ana de Viya, 21
11009-Cádiz.
España
Teléfono / Phone: + 34 956 24 50 08
email:
perdomogm@yahoo.com
El
interés científico
de nuestro grupo de investigación
es el estudio del síndrome metabólico. En concreto,
estamos interesados en
comprender las alteraciones metabólicas que tienen lugar durante
la obesidad y
las patologías asociadas como la diabetes tipo 2 y la enfermedad
cardiovascular. Para este fin, empleamos técnicas de
biología molecular,
genética y bioquímica en líneas celulares y
modelos preclínicos de
investigación en animales. /
Our research interest is focused on
the metabolic syndrome. We are interested to understand the
pathophysiology and
the molecular mechanism that link obesity and its associated
pathologies (i.e.
cardiovascular disease diabetes and insulin resistance). To approach
these
questions we employ different methodologies including molecular
biology,
biochemistry and mouse models of obesity and insulin resistance.
Líneas
de Investigación: 1) Apolipoproteínas y
metabolismo lipídico; 2)
Inmunosupresión y dislipidemia; 3) Obesidad y resistencia a la
insulina. /
Research
lines: 1) Apolipoproteins and lipid metabolism, 2)
Immunosuppression and
dyslipidemia, 3) Obesity and insulin resistance.
Publicaciones representativas / Representative
publications:
1. PERDOMO G and Dong
HH. (2009)
Apolipoprotein D in Lipid Metabolism and Its Functional Implication in
Atherosclerosis and Aging.
Aging 1:17-27
2. Su D, Coudriet GM,
Kim
DH, Lu Y, PERDOMO G, Qu S, Slusher S, Tse HM, Piganelli J, Giannoukakis
N,
Zhang J, Dong HH. (2009) FoxO1 Links Insulin Resistance to
Proinflammatory Cytokine IL-1beta Production
in Macrophages.
Diabetes. En Prensa / in press
3.
PERDOMO G,
Martinez-Brocca AM, Bhatt BA, Brown NF. O´Doherty RM and
García-Ocana A. (2008) Hepatocyte growth factor is a novel
stimulator of glucose uptake and metabolism
in skeletal muscle cells.
J. Biol. Chem. 283(20):13700-6
4. Kamagate A, Qu S,
PERDOMO G, Su D, Kim DH,
Slusher S, Meseck M and Dong HH. (2008) FoxO1 mediates
insulin-dependent regulation of hepatic VLDL production in mice. J Clin
Invest. 118(6):2347-64
5.
Stefanovic-Racic
M., PERDOMO G., Mantell B., Sipula
I., Brown N.
and O'Doherty, R (2008) A moderate increase in carnitine
palmitoyltransferase I activity is sufficient
to substantially reduce hepatic triglyceride levels. Am J Physiol
Endocrinol Metab. 294 (5)
E969-77
6. Zhang L., PERDOMO
G., Kim DH., Qu S.,
Ringquist S., Trucco M and Dong HH. (2008) Proteomic analysis of
fructose-induced fatty liver in hamsters. Metabolism 57 (8):
1115-24
7. Qu S., PERDOMO, G.,
Su D., D’Souza FM.,
Shachter NS. and Dong HH. (2007) Effects of ApoA-V on VLDL and HDL
metabolism in hypertriglyceridemic APOC3
transgenic mice. J. Lipid Res. 48 (7):1476-87
8. Brown N.,
Stefanovic-Racic, M.,. Sipula I.
and PERDOMO, G. (2007) mTOR regulates lipid metabolism in
primary cultures of rat hepatocytes. Metabolism 56 (11): 1500-7
9. Qu
S., Su D., Altomonte J., Kamagate A., He J., PERDOMO, G Tse T., Yiang
Y. and
Dong HH. (2007) PPAR-a mediates the hypolipidemic action of
fibrates by antagonizing FoxO1. Am J Physiol Endocrinol Metab. 292 (2):
E421-34
10.
Sipula I, Brown N and PERDOMO, G.
(2006) Rapamycin-mediated inhibition of mammalian target of rapamycin
in skeletal
muscle cells reduces glucose utilization and increases fatty acid
oxidation. Metabolism 55 (12): 1637-44
11. Altomonte J.,
PERDOMO, G., He J., Fan Y.,
Kamagate A., Meseck M. and Dong HH. (2006) Aberrant Forkhead box O1
function is associated with impaired hepatic metabolism. Endocrinology
147 (12): 5641-52
12.
PERDOMO, G.,
Commerford SR., Richard A-M., Adams S., Corkey BE, O’Doherty RM
and Brown N. (2004) Increased b-oxidation in muscle cells enhances
insulin-stimulated glucose
metabolism and protects against fatty acid-induced insulin resistance
despite
intramyocellular lipid accumulation. J. Biol. Chem.
279 (26): 27177-86
13. Sinha S., PERDOMO,
G., Brown F and O’Doherty
RM. (2004) Fatty acid-induced insulin resistance in L6 myotubes
requires nuclear
translocation of NkB. J. Biol. Chem 279 (40): 41294-301
This
page was last updated on December 3rd, 2009. Please send comments to perdomogm@yahoo.com
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